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 Osteoporosis is reduced Bone Mineral Density (BMD), particularly in post-menopausal women, but it can occur in men and younger women. It is caused by more bone cells being resorbed than being deposited. This imbalance results in a progressive loss of bone density and a thinning of bone tissue.
 
Researchers estimate that about 1 out of 5 American women over the age of 50 have osteoporosis. About half of all women over the age of 50 will have a fracture of the hip, wrist, or vertebra (bones of the spine).
 
Prevention:The risk of Osteoporosis can be reduced with hormone replacement therapy, supplements e.g. Calcium and Vitamin D and other medication (see below).
 
Exercise with weights can help improve bone density and avoid Osteoporosis.
   
Treatment:Estrogen therapy / hormone therapy:  These are therapies only for women that consist of estrogen alone or estrogen combined with progestin.
 
Selective Estrogen Receptor Modulators (SERMs): These medications interact with estrogen receptors, providing a protective effect on bone.
 
Medications to treat osteoporosis fall into two main categories:  antiresorptives and anabolics.Antiresorptives slow  loss of Bone Mineral Density (BMD).   Antiresorptive medications include alendronate (brand name Fosamax®), risedronate (brand name Actonel®) and zoledronic acid (brand name Reclast®). These medications are in a class of drugs called bisphosphonates.
 Anabolics speed up bone formation.  Teriparatide (brand name Forteo®), was the first to be approved.
 
Calcitonin:   This is a hormone that helps regulate calcium and bone processes.
 
Links:Osteoporosis at National Osteoporosis Foundation (NOF.org)
 U.S. National Library of Medicine (www.nlm.nih.gov)
 Osteoporosis Treatment Options - Strong to the Bone
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last updated 23 Aug 2009 |